Trends in Adjuvant and Vaccine Delivery Systems

Trends in Adjuvant and Vaccine Delivery Systems

Since time immemorial, adjuvants have played a very crucial role in a vaccine formulation. Mere antigen discovery does no good until unless combined with an effective adjuvant. The modern era of vaccinology has transcended way beyond the conventional approach of prophylaxis, where it is driven more towards achieving specific and targeted effects. With the health sector alarmed with the dawn of ...

Helicobacter pylori vaccine: mucosal adjuvant & delivery systems.

Vaccination, especially mucosal vaccination, is considered to be effective in the management of Helicobacter pylori infections. However, most antigens alone cannot induce immune responses when administered mucosally and need to be co-administered with adjuvants or delivery systems. The current research on the mucosal adjuvant and delivery systems of vaccine against H. pylori, including advantag...

Characterizing and controlling the loading of Vipera albicornuta venom in chitosan nanoparticles as an adjuvant and vaccine delivery system

The aim of this study was designing and preparing the chitosan nanoparticles (CS-NPs) loading with snake (Vipera albicornuta) venom as well as evaluating the influence of different factors on the encapsulation efficiency (EE) and loading capacity (LC) of venom. The morphologies and characteristics of CS-NPs were determined by scanning electron microscopy (SEM), Fourier transform infrared spectr...

trends in design and evaluation of drug delivery systems

Alginate Nanoparticles as a Promising Adjuvant and Vaccine Delivery System

During last decades, diphtheria has remained as a serious disease that still outbreaks and can occur worldwide. Recently, new vaccine delivery systems have been developed by using the biodegradable and biocompatible polymers such as alginate. Alginate nanoparticles as a carrier with adjuvant and prolong release properties that enhance the immunogenicity of vaccines. In this study diphtheria tox...